Session IV-6: Broadening the application of Refinement Session IV-6: Oral presentations

نویسندگان

  • L. F. Mikkelsen
  • J. L. Ottesen
  • N. Dragsted
چکیده

Blood sampling is one of the most common experimental procedures performed on laboratory animals for the analysis of biochemical, metabolic, toxicological and immunological parameters or the production of antibodies. Sampling of sufficient volumes of blood in mice and rats can be challenging due to the relatively small size of animals. All sampling methods should be evaluated and the use of the most appropriate technique for the specific purpose and species or subspecies is important. Sampling by trained and competent staff is essential for ensuring that any pain, distress or discomfort is kept to a minimum. Minimisation of such adverse effects is further important for scientific as well as ethical and legal reasons, since they can cause biological changes which may affect the blood sample, and hence the validity of the research results and the number of animals used to achieve the scientific objective. This presentation will summarize and discuss a number of recent published papers and unpublished studies performed at Novo Nordisk or within the Danish CALAR research collaboration (www.calar.dk) combined with relevant references in order to evaluate quality of plasma sampled by different methods, e.g. amputation of the tail tip, lateral tail incision, puncture of the tail tip and periorbital puncture, for multiple blood sampling. Animal welfare implications, advantages and disadvantages, based on scientific analysis, telemetric recordings and intense observations, by using methods like submandibular blood sampling in standard and genetically modified mice and sublingual blood sampling in rats will further be presented and discussed. IV-6-078 Refined blood sampling of rodents

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تاریخ انتشار 2011